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KMID : 0613820180280121507
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Journal of Life Science
2018 Volume.28 No. 12 p.1507 ~ p.1515
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Effects of Corni Fructus on Testosterone-induced Benign Prostatic Hyperplasia in Sprague Dawley Rats
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Kwon Da-Hye
Hwang Young-Hoon
Choi Eun-Ok
Kim Min-Young
Ji Seon-Yeong
Kim Kyung-Il
Park No-Jin
Kim Sung-Ok
Hong Su-Hyun
Park Cheol
Hwang Hye-Jin
Jeung Ji-Suk
Choi Yung-Hyun
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Abstract
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Benign prostatic hyperplasia (BPH) is characterized by prostatic hypertrophy mainly in the elderly. Corni Fructus is reportedly effective in the prevention and treatment of various diseases, but its efficacy on BPH has not been previously studied. In the present study, we investigated whether or not a Corni Fructus water extract (CF) could prevent testosterone-induced prostatic hyperplasia in rats. To induce BPH, castrated rats were subcutaneously injected with testosterone propionate (TP). CF was administered daily by oral gavage, along with the TP injections, and finasteride, a selective inhibitor of 5α-reductase type 2, was used as a positive control. The results show that CF significantly reduces prostate weight and histopathologic changes while also decreasing levels of serum dihydrotestosterone, similar to the finasteride-treated group. CF also suppresses TP-induced 5α-reductase expression and concentration in prostate tissue and serum, respectively. Furthermore, CF markedly inhibited TP- induced expression of the androgen receptor (AR) and the steroid receptor coactivator 1, an AR coactivator, which was associated with a decrease in prostate-specific antigen levels in both serum and prostate tissue. In conclusion, the results of this study indicate that CF weakens BPH status by inactivation of 5α-reductase and AR.
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KEYWORD
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Androgen receptor, benign prostatic hypertrophy, Corni Fructus, prostate specific antigen, 5α-reductase
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